Tumor microenvironment and Tumor Endothelial Cells

Mast Cells and Tumor Microenvironment

Abstract Increasing evidence indicates that a unique immune cell, the mast cell, accumulates in the stroma surrounding certain tumors, especially mammary and pancreatic adenocarcinoma, as well as melanoma. Many molecules secreted by mast cells could benefit the tumor in at least four ways: (1) angiogenin, heparin and vascular endothelial growth factor (VEGF), which induce neovascularization; (2...

Microenvironment and Immunology Tumor Endothelial Cells with Distinct Patterns of TGFb-Driven Endothelial-to-Mesenchymal Transition

Endothelial-to-mesenchymal transition (EndMT) occurs during development and underlies the pathophysiology of multiple diseases. In tumors, unscheduled EndMT generates cancer-associated myofibroblasts that fuel inflammation and fibrosis, and may contribute to vascular dysfunction that promotes tumor progression. We report that freshly isolated subpopulations of tumor-specific endothelial cells (...

Lung Tumor Microenvironment and Myelomonocytic Cells

Interplay between Tumor Microenvironment and Cancer Cells

Copyright © 2016 Kallesh D. Jayappa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Cancer cell interaction with microenvironment plays a very important role in cancer cell survival, proliferation, and/or metastasis. The ca...

Tumor endothelial cells accelerate tumor metastasis

Tumor metastasis is the main cause of cancer-related death. Understanding the molecular mechanisms underlying tumor metastasis is crucial to control this fatal disease. Several molecular pathways orchestrate the complex biological cell events during a metastatic cascade. It is now well known that bidirectional interaction between tumor cells and their microenvironment, including tumor stroma, i...